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Thursday, August 6, 2020 | History

3 edition of Chemogenomics in drug discovery found in the catalog.

Chemogenomics in drug discovery

a medicinal chemistry perspective

  • 365 Want to read
  • 12 Currently reading

Published by Wiley-VCH in Weinheim .
Written in English

    Subjects:
  • Pharmacogenetics.,
  • Combinatorial Chemistry Techniques.,
  • Drug Design.,
  • Genomics.,
  • Drug development.,
  • Pharmaceutical chemistry.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Hugo Kubinyi and Gerhard Müller.
    SeriesMethods and principles in medicinal chemistry -- v. 22.
    ContributionsKubinyi, Hugo., Müller, Gerhard, 1963-
    The Physical Object
    Paginationxxiv, 463 p. :
    Number of Pages463
    ID Numbers
    Open LibraryOL18221322M
    ISBN 10352730987X

    Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. Here, we present several example of how chemogenomics is enabling drug discovery by elucidating the relationship between the physico-chemical properties of molecular binding sites and ligands. A survey of the known landscape of proteins expressed from the human genome, for which leads have been discovered or by orthology are predicted to be druggable, present the .

    / A Structural Framework for GPCR Chemogenomics: What’s In a Residue Number?. Computational Methods for GPCR Drug Discovery. editor / Alexander Heifetz. Humana Press Inc, pp. (Methods in Molecular Biology).   * Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.2/5(1).

    Chemogenomics: drug discovery's panacea? - Molecular BioSystems (RSC Publishing) Chemogenomics aims towards the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The aim of this Special Issue is to highlight recent efforts in all aspects of “Chemogenomics in Drug Discovery”. We invite your submission describing the design of or use of chemogenomic sets. Contributions may also include the design, synthesis, and screening of protein family directed compounds.


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Chemogenomics in drug discovery Download PDF EPUB FB2

"Chemogenomics in Drug Discovery" offers a practical definition of chemogenomics in order to foster a clear understanding of this genome-wide drug-discovery approach. The book is valuable for graduate students anf for academic and industrial researchers who want to learn about modern drug-discovery Chemogenomics in drug discovery book.

"Chemogenomics in Drug Discovery" offers a practical definition of chemogenomics in order to foster a clear understanding of this genome-wide drug-discovery approach. The book is valuable for graduate students anf for academic and industrial researchers who want to learn about modern drug-discovery approaches.".

Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to : Hardcover.

texts All Books All Texts latest This Just In Smithsonian Libraries FEDLINK (US) Genealogy Lincoln Collection. National Emergency Library. Top Chemogenomics in Drug Discovery Item Preview remove-circle Share or Embed This Item. EMBED EMBED (for Pages: Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead the combined expertise of 20 research.

“Chemogenomics in Drug Discovery” offers a practical definition of chemogenomics in order to foster a clear understanding of this genome‐wide drug‐discovery approach.

The book is valuable for graduate students and for academic and industrial researchers who want to learn about modern drug‐discovery approaches. that is entitled “Chemogenomics in Drug Discovery: A Medicinal Chemistry Perspective”, the attempt is made to provide a valid definition of chemogenomics in the context of drug discovery, more specifically in the context of medicinal chemistry.

Chemogenomics in Drug Discovery, Wiley-VCH,pp. „The most fruitful basis for the discovery of a new drug is to start with an old drug“ Sir James Black, Nobel Prize N N N H N Me OH Ki musc M1 = 3 nM N N N H N Ki AChE = 10 nM N N N H N Me O minaprine (antidepressant) N N N N Me IC50 5-HT3 = 10 nM Hugo Kubinyi O O N Me.

Discusses the discovery of agents for the treatment and management of bacterial infections, Parkinson's disease, psoriasis, ulcers and stomach pain, atopic dermatitis, asthma, and cancer. Contains chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics.

Chemogenomic screening has the potential to expedite the conversion of phenotypic screening projects into target-based drug discovery approaches.

Other applications include drug repositioning, Cited by: In response, chemogenomics, a new approach that guides drug discovery based on gene families, has been developed.

By integrating all information available within a protein family (sequence, SAR data, protein structure), chemogenomics can efficiently enable. Pharmacogenomics is considered the future of drug therapy.

It is a rapidly growing area in the recognition of the necessity of personalized medicine, a medicine that deals with the complexity of the human body.

Free Books PDF: Pharmacogenomics in Drug Discovery and Development – Because of the diversity of patients’ biological backgrounds, the same [ ]. Target validation in drug discovery generally involves characterizing the pharmacological response resulted from modulating the activity of a target protein.

The chemogenomic approach utilizes small molecules as tools to establish the relationship between. In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines.

Addressing this challenge, chemogenomics aims to identify systematically all ligands. With the most comprehensive and up-to-date overview of structure-based drug discovery and using experimental and computational approaches, this book covers principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug.

accelerate the pace of the drug-discovery the past couple of years,many leading pharmaceutical drug development companies have established chemoge-nomics groups,and hundreds of novel targets and com-pounds that have been identified by chemogenomics are currently undergoing biological testing further along the drug-development pipeline.

Overall, GCDB will be helpful in target identification and glaucoma chemogenomics data exchange and sharing, and facilitate drug discovery for glaucoma treatment. Introduction Glaucoma, which affects 60–70 million people worldwide, is a painless neurodegenerative disorder and the second cause of blindness after cataracts, resulting in Cited by: 1.

Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery.

Chemogenomics knowledge-based drug discovery approaches aim to extract the knowledge gained from one target and to apply it for the discovery of ligands and hopefully drugs of a.

Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead design.

Chemogenomics integrates target and drug discovery by using active compounds (or ligands) as probes to characterize proteome functions. As in genetics, forward and reverse principles can be Cited by: Chemogenomics in Drug Discovery. EMBED (for hosted blogs and item tags).Chemogenomics is a new strategy in drug discovery which, in principle, searches for all molecules that are capable of interacting with any biological target.

Because of the almost infinite number of drug-like organic molecules, this is an impossible by: